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Selectively Permeable In Cell Membrane

In this selectively permeable in cell membrane post we have briefly explained about selectively permeable in cell membrane.

Selectively Permeable In Cell Membrane

Plasma membranes are asymmetric, which means that the interior and exterior of the membrane are not identical. In fact, there is a significant difference in the arrangement of phospholipids and proteins between the two leaflets that form a membrane. Some proteins on the membrane’s interior serve to anchor the membrane to cytoskeleton fibres. 

Peripheral proteins on the membrane’s surface bind extracellular matrix elements. Carbohydrates that are attached to lipids or proteins can also be found on the plasma membrane’s outer surface. These carbohydrate complexes assist the cell in binding extracellular fluid substances that the cell requires. This contributes significantly to plasma membrane selectivity.

Selective Permeability of Cell Membrane

Selectively Permeable In Cell Membrane

Remember that plasma membranes are amphiphilic, which means that they have both hydrophilic and hydrophobic regions. This property facilitates the passage of some materials through the membrane while impeding the passage of others. Lipid-soluble material with a low molecular weight can easily pass through the membrane’s hydrophobic lipid core. 

Fat-soluble vitamins A, D, E, and K, for example, easily pass through plasma membranes in the digestive tract and other tissues. Drugs and hormones that are fat-soluble also enter cells easily and are easily transported into the body’s tissues and organs. Because oxygen and carbon dioxide molecules have no charge, they pass through membranes via simple diffusion.

Polar substances cause issues for the membrane. While some polar molecules can easily connect to the outside of a cell, they cannot easily pass through the plasma membrane’s lipid core. Furthermore, while small ions could easily pass through the mosaic of the membrane’s spaces, their charge prevents them from doing so. 

Ions like sodium, potassium, calcium, and chloride must have a unique way of penetrating plasma membranes. Simple sugars and amino acids require assistance with transport across plasma membranes, which are accomplished by a variety of transmembrane proteins (channels).


The plasma membrane’s interior and exterior surfaces are not identical, which contributes to the membrane’s selective permeability. Fat-soluble substances can easily pass through the plasma membrane’s hydrophobic interior and diffuse into the cell. Polar and charged molecules do not diffuse easily through the plasma membrane’s lipid core and must be transported across by proteins, sugars, or amino acids.

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